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May 07,  · Yohimbine which has been naturally extracted from the yohimbe plant is legal for sale, but yohimbine HCL which has been synthetically manufactured is considered a prescription drug. Uses for Yohimbine. Consumers often buy yohimbine to improve erectile function and support sexual health.5/5(1). Some forms of Yohimbine require a prescription to buy in the US. Yohimbine HCL which is a synthetic ingredient, and cannot be used in dietary supplements is a pharmaceutical drug used for treating sexual dysfunction and impotence.